Nos encontramos ante el pensamiento jurídico de uno de nuestros principañes representantes de la lengua castellana: Fray Luis de León. Esta reflexión leoniana contenida y expresada en el tratado De legibus completa y supera en algunos aspectos la refexión.

Automatic control of physiological variables is one of the most active areas in biomedical engineering. This paper is centered in the prediction of the analgesic variables evolution in patients undergoing surgery. The proposal is based on the use of hybrid intelligent modelling methods. The study considers the Analgesia Nociception Index to assess the pain in the patient and remifentanil as intravenous analgesic. The model proposed is able to make a one-step-ahead prediction of the remifentanil dose corresponding to the current state (...) of the patient. The input information is the previous remifentanil dose, the ANI variable and the electromyogram signal. Modelling techniques used are Artificial Neural Networks and Support Vector machines for Regression combined with clustering methods. Both training and validation were done with a real dataset from different patients. Results obtained show the potential of this methodology to calculate the drug dose corresponding to a given analgesic state of the patient. (shrink)

The English translation of Jörn Rüsen’s Historik is a major event in the global community of the theory of history. Few contemporary thinkers in this field have been so systematic and comprehensive as Rüsen. This book, rendered as Evidence and Meaning, is the outcome of a whole life devoted to the renewal of German historicism. Rüsen’s contribution mirrors the great debates held in West Germany since the 1960s about the theory of history, discussions that prompted a conjoint reassessment of the (...) old dispute between historicist academia and Marxist or Weberian sociologism, including the consequences of the linguistic turn. Rüsen has opened the German historicist tradition toward spaces of compromise with the Western “scientific” or more generalizing history. Furthermore, Rüsen’s synthetic historicism, with its insistence on praxis, might be taken as a case of convergent evolution between German and American syntheses of historical life and historical knowledge. (shrink)

Se estudian los conceptos claves de fortuna, virtù y gloria, con elobjeto de buscar algunas aclaraciones sobre el problema de larelación entre moral y política en Maquiavelo. La virtù maquiavelianaincluye, sin duda, múltiples componentes de energía, talento,pero no está completamente exenta de elementos morales. Delconcepto de fortuna podemos extraer una serie de criterios parala acción política que forman parte de la virtù maquiaveliana, lacual, si bien se aleja de la moral cristiana vigente en su tiempo, lesitúa dentro de una moral (...) republicana. Del examen del conceptode gloria descubrimos cómo la gloria es recompensa de la virtù,pero no se reconoce a cualquier político que tiene éxito en susempresas, sino solo a quien salva a la patria y lo hace con mediosbenignos. (shrink)

La lectura de los clásicos, el estudio de la historia y la atenta observación de la práctica política de su tiempo le llevarán a Maquiavelo a romper con la tradición humanista sobre la propiedad y a defender la necesidad de limitaciones sobre la misma. Su concepción republicana sobre la propiedad se concentra en el lema de que la ciudad sea rica y los ciudadanos pobres. Esto supone una política de moderación que excluye por igual la concepción oligárquica de quienes confunden (...) la riqueza de la ciudad con la de sus gobernantes; así como el igualitarismo radical de los que niegan con su exclusivismo la existencia de los dos humores que debidamente coordinados hacen que una república, con un gobierno mixto, sea segura, estable y rica. (shrink)

Cancer is a singular cellular state, the emergence of which destabilises the homeostasis reached through the evolution to multicellularity. We present the idea that the onset of the cellular disobedience to the metazoan functional and structural architecture, known as the cancer phenotype, is triggered by changes in the cell's external environment that occur with ageing: what ensues is a breach of the social contract of multicellular life characteristic of metazoans. By integrating old ideas with new evidence, we propose that with (...) ageing the environmental information that maintains a multicellular organisation is eroded, rewiring internal processes of the cell, and resulting in an internal shift towards an ancestral condition resulting in the pseudo‐multicellular cancer phenotype. Once that phenotype emerges, a new local social contract is built, different from the homeostatic one, leading to tumour formation and the foundation of a novel local ecosystem. (shrink)

En su libro The Tapestry of Reason: An Inquiry into the Nature of Coherence and its Role in Legal Argument,1 Amalia Amaya argumenta las ventajas de adoptar una postura coherentista en el derecho. Concretamente, su tesis principal es la siguiente...

One of the protagonists of the darwinist controversy in the Canary Islands (Spain), during the Nineteenth Century, was the advocate and teacher Rafael Lorenzo y García. In this paper, I show his original thought, until now unknown, against the classical darwinism and next to the fixism.Moreover I analyse the philosophical and natural constants in his Estudios filosóficos (1876 y 1877).

The creation of a citizen militia is a characteristic pretension of the Renaissance republicanism. The republic cannot lack defense nor defend themselves with mercenary armies. For Machiavelli, Guicciardini or Giannotti the citizen has a set of virtues, like austerity, discipline, patriotism or bravery, that make him the best soldier. Therefore, the Republican regime needs the citizens to be soldiers, because the military discipline itself is a means necessary to forge such civic virtues without which no republic can survive.

Este trabajo aborda la realidad actual de los medios de comunicación de masas y cómo los mitos del liberalismo a propósito de la libertad de expresión han sido sistemáti-camente destruidos. La tesis liberal de la separación entre lo público y lo privado ha desaparecido porque todas las empresas de comunicación están subordinadas al Estado. La confianza en el libre mercado ha producido la mayor concentración de empresas mediáticas. El "cuarto poder" no contribuye a la limitación del poder del Estado. La (...) lucha por la verdad ha sido sustituida por la manipulación de la opinión pública y por la mentira a favor del gobierno. (shrink)

The enthymeme is essential because it reflects what humans do when they think. It provides an effective pedagogical approach to the analysis and synthesis of ideas in the classroom. In this volume, such an approach is applied to various areas of content for the purpose of helping students prepare themselves for the challenges of modern life.

Este trabajo examina cómo, para ocupar la tribuna vacante del filósofo-orador José Ortega y Gasset, el exiliado Eduardo Nicol elaboró el emergente problema contemporáneo de la relación entre retórica y filosofía. Esta cuestión atañe tanto al qué como al para qué de la filosofía. ¿Hay un “grado cero” retórico en el pensamiento? Y si existe, ¿es el grado óptimo, considerando la meta humana de la filosofía? Nicol respondió ambas preguntas avanzando sobre la semiótica fenomenológica de Husserl, para establecer en la (...) comunicación humana la constitución simultánea de expresión, significación y objetividad; y renunciando a la brillantez ensayística de Ortega como paradigma de influencia cultural de la filosofía. Pero, en el primer camino, no extrajo todas las consecuencias de su expresionismo; en el segundo, hubo de admitir una norma retórica algo diferente del grado cero, ya que la humanidad estaba en peligro. El caso de Nicol, en diálogo con todas las corrientes de la filosofía contemporánea, reafirma el lugar central que en ellas viene ocupando la semiótica. (shrink)

La discapacidad ha sido concebida a lo largo del tiempo de diferentes modos, lo cual fue ocasión para que algunos autores construyeran modelos para explicar ciertas praxis en torno al tema. Este artículo traza un recorrido desde el primer modelo hasta la actualidad. A su vez propone un nuevo, el Modelo de Comunicación y Reconocimiento Legítimo de la Discapacidad (MCRLD), el cual se caracteriza por un cambio de paradigma: pasar de la inclusión al reconocimiento. Para fundamentar esto, se presentan sus (...) tres categorías: reconocimiento, distancia y vulnerabilidad. También se expondrán las diferentes teorías y conceptos que lo sustentan. El propósito del MCRLD es profundizar en la idea del empoderamiento de las personas con discapacidad como parte de la diversidad de la sociedad, acortando brechas históricamente construidas y aún vigentes. (shrink)

En el presente, se ofrece una breve reconstrucción histórica de la evolución de la Filosofía y la Historia de la Ciencia hasta hoy y, además, una visión panorámica del estado actual de ambas disciplinas.

I will center the discussion of the Hart-Fuller debate on the five claims Hart mentions might be understood as legal positivisms main tenets: (1) the command theory; (2) the no necessary connection thesis; (3) the methodological claim; (4) the charge of positivism as formalism and the problem of interpretation; and (5) the meta-ethical confusion. In light of these five claims, I will explore whether the exchange of views between Hart and Fuller in 1957 truly amounted to a debate. Sorting out (...) this issue is the aim of this article. (shrink)

La solidaridad, entendida como una operación social y comunicativa destinada a mantener la cohesión de las personas en el marco de la sociedad moderna, pone en evidencia la permanencia de un orden social estratificado que produce exclusión de ciertos derechos sociales. El presente artículo, intenta discutir más a fondo esta definición ofreciendo un análisis empírico y multidimensional de las conductas solidarias en Chile. Mediante análisis bivariados y de MANOVA de los datos de la “Encuesta de solidaridad 2010” (N=1389) generada por (...) el centro de medición MIDE UC de la Pontificia Universidad Católica, llegamos a la conclusión que existen ciertas variables del esquema de estratificación social que en la actualidad predicen y direccionan la orientación de la solidaridad en Chile. Esto sugiere que la solidaridad no solamente responde a una esquematización estratificada de la sociedad moderna, sino además agrega que diferentes ejes de estratificación social influencian las dimensiones de la solidaridad. (shrink)

Background: Heart rate variability (HRV) has been considered as a measure of heart-brain interaction and autonomic modulation, and it is modified by cognitive and attentional tasks. In cognitive tasks, HRV was reduced in participants who achieved worse results. This could indicate the possibility of HRV predicting cognitive performance, but this association is still unclear in a high cognitive load sport such as chess Objective: To analyse modifications on HRV and subjective perception of stress, difficulty and complexity in different chess problem (...) tasks. Design: HRV was assessed at baseline. During the chess problems, HRV was also monitored, and immediately after chess problems the subjective stress, difficulty and complexity were also registered. Method: A total of 16 male chess players, age: 35.19 (13.44) and ELO: 1927.69 (167.78) were analysed while six chess problem solving tasks with different level of difficulty were conducted (two low level, two medium level and two high level chess problems). Participants were classified according to their results into two groups: high performance or low performance. Results: Friedman test showed a significant effect of tasks in HRV indexes and perceived difficulty, stress and complexity in both high and low performance groups. A decrease in HRV was observed in both groups when chess problems difficulty increased. In addition, HRV was significantly higher in the high performance group than in the low performance group during chess problems. Conclusions: An increase in autonomic modulation was observed to meet the cognitive demands of the problems, being higher while the difficulty of the tasks increased. Non-linear HRV indexes seem to be more reactive to tasks difficulty, being an interesting and useful tool in chess training. (shrink)

En este artículo analizamos los límites intrínsecos de nociones como la «dignidad humana» y otros análogos interculturales a la luz de la asimetría ineludible que imponen las reglas inherentes de inclusión, exclusión y jerarquía de todo lenguaje. En este marco, analizamos la excepcionalidad que supone la dignidad humana para el concepto mismo de los derechos humanos. Sobre esa base, sostenemos que es imperativo mantener diferenciados los privilegios que reconocemos a los animales humanos, de los derechos que reconocemos a otros animales (...) no humanos, sin que ello implique argumentar en desmedro de estos últimos. Finalmente, en el marco del análisis epistemológico y lingüístico, reconocemos el carácter paradójico e ineludible de los derechos humanos, que impone «violentamente» un orden de sentido que, en última instancia, parecen fundarse en la exclusiva voluntad del legislador. (shrink)

When recalling autobiographical events, people not only retrieve event details but also the feelings they experienced. The current study examined whether people are able to consistently recall the intensity of past feelings associated with two consequential and negatively valenced events, i.e. the 9/11 attack (N = 769) and the COVID-19 pandemic (N = 726). By comparing experienced and recalled intensities of negative feelings, we discovered that people systematically recall a higher intensity of negative feelings than initially reported – overestimating the (...) intensity of past negative emotional experiences. The COVID-19 dataset also revealed that individuals who experienced greater improvement in emotional well-being displayed smaller biases in recalling their feelings. Across both datasets, the intensity of remembered feelings was correlated with initial feelings and current feelings, but the impact of the current feelings was stronger in the COVID-19 dataset than in the 9/11 dataset. Our results demonstrate that when recalling negative autobiographical events, people tend to overestimate the intensity of prior negative emotional experiences with their degree of bias influenced by current feelings and well-being. (shrink)

El correcto mantenimiento de las zonas donde se alojan los perros y el uso de repelentes es fundamental para la prevención de la transmisión de esta enfermedad.

This paper presents an overview of my work in philosophy from my first book on Friedrich Schiller and the political sublime to my most recent project on listening to traumatic forms of violence. Starting with a reflection on the autobiographical character of philosophy, I propose to take up the question of an aesthetic dimension of philosophical critique, where aesthetics is understood as an always already embodied perspective on the world, on truth, and on philosophical activity, as well as an always (...) already political realm, where the distribution of sense pre-determines our approach and articulation of experience. Departing from aesthetics understood and deployed as critique, the paper moves on to ask about the specific frameworks of sense or grammars that determine in advance the conditions of audibility in the realms of memory-building and history-making—particularly in those contexts where historical, political, and institutional forms of violence produce silencing and erasure. Putting in dialogue the latter with decolonial studies, I (re)interpret “traumatic violence” as a colonizing form of violence, understanding that one of its central aspects is that it is not only an assault on life but on the conditions of production of sense that make life legible as such. In this context, my project on grammars of listening seeks to carefully unpack these complex intersections while also explaining why I believe that a radical form of listening is an essential subversive/imaginative strategy against traumatic/colonial violence. (shrink)

Psychological flexibility is a key concept of acceptation and commitment therapy. This factor has been linked with psychological wellbeing and associated factors, such as quality of life, in cancer patients. These and other positive results of acceptation and commitment therapy in cancer patients found in previous research could be enhanced by using mhealth tools. A three-arm randomized superiority clinical trial, with a pre-post-follow-up repeated measures intergroup design with a 1:1:1 allocation ratio is proposed. A hundred and twenty cancer patients will (...) be randomly assigned to one of the following interventions: face-to-face ACT + mobile application, face-to-face ACT, and Waitlist control group. The primary expected outcome is to observe significant improvements in psychological flexibility acceptance and action questionnaire- II in the face-to-face ACT + app group, after comparing baseline and post-treatment scores, and the scores will remain stable in the two assessment points, 3 and 6 months after the intervention. Secondary expected outcomes are significant increasing scores in quality of life and post-traumatic-growth, and significant decreasing scores in anxiety and depression, insomnia and fatigue at the same assessment points. Also, it is expected that the scores of this group will be higher than the scores of the face-to-face ACT group and the waitlist control group. This study aims to assess the efficacy of a combined intervention for psychological flexibility and associated symptoms in cancer patients. The results of this protocol may help to consider the use of acceptation and commitment therapy and mhealth applications in cancer settings as a valid therapeutic choice.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT05126823]. (shrink)

This article presents a scientometric study regarding entrepreneurship and its relationship with wellbeing. The study presents a systematic review and measures impact and relational character to identify the relevance of countries, research organizations, and authors in the field of entrepreneurial wellbeing. The study poses the following research questions: What is the nature of the evolution of scientific knowledge in the entrepreneurial wellbeing field? What is the nature of the concentration in terms of geographical distribution and co-authorship level of knowledge production (...) in the entrepreneurial wellbeing field? What are the knowledge trends in knowledge production for entrepreneurial wellbeing literature? The contribution of this research is two-fold. First, in terms of methodology, it contributes study into the use of a more robust approach to search for the scientometric trends about entrepreneurship wellbeing in addition to the PRISMA review tools and the PICOS eligibility criteria. Secondly, the study presents research updates in the search for results for the last 2 years of knowledge production. This upgrade is particularly important in a research field that presents exponential growth, where 2019 and 2020 presented almost double the amount of knowledge production compared to 2017 and 2018. (shrink)

In this work, we present a new approach to solve the location management problem by using the reporting cells strategy. Location management is a very important and complex problem in mobile computing which aims to minimize the costs involved. In the reporting cells location management scheme, some cells in the network are designated as reporting cells . The choice of these cells is not trivial because they affect directly to the cost of the mobile network. This article is focused on (...) the use of high performance computing to execute a parallel heuristic that places optimally the RCs in a mobile network, minimizing its total cost. The main goal of this work is to demonstrate that the collaborative work of different evolutionary algorithms can obtain very good results. For this reason, we have implemented a parallel heuristic and six evolutionary algorithms that works in a parallel way on a cluster to solve the RCs problem. (shrink)

Surgical patient safety remains a concern worldwide as, despite World Health Organization recommendations and implementation of its Surgical Safety Checklist, adverse events continue to occur. The aim of this qualitative study was to explore the views and experiences of perioperative nurses regarding the factors that impact surgical patient safety. Data were collected through five focus groups involving a total of 50 perioperative nurses recruited from four public hospitals in Spain. Content analysis of the focus groups yielded four main themes: personal (...) qualities of the perioperative nurse, the surgical environment, safety culture, and perioperative nursing care plans. One of the main findings concerned barriers to the exercise of leadership by nurses, especially regarding completion of the Surgical Safety Checklist. Some of the key factors that impacted the ability of perioperative nurses to fulfil their duties and ensure patient safety were the stress associated with working in the operating room, time pressures, and ineffective communication in the multidisciplinary team. Targeting these aspects through training initiatives could contribute to the professional development of perioperative nurses and reduce the incidence of adverse events by enhancing the surgical safety culture. (shrink)